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Increases SIRT-1 activity as a result of enhanced NAD+ salvage, leading to beneficial epigenetic and metabolic reprogramming, including increased oxidative phosphorylation (OXPHOS) and muscle stem cell activation 1-3

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This extensive gene modulation appears to reset gene expression patterns toward healthier, more youthful states

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Phase 4: AOD 9604 cycle break (week 17+) After 12-16 weeks of AOD 9604, discontinue it for a 4-week break while continuing tirzepatide